Hematology Journal of Blood Science and Disorders
New Reference Values of Arterial Blood Pressure in Term Newborns
Abstract
Oksana V Shumakova and Ekaterina L Bokerija
Background Previous arterial blood pressure (BP) values reference in term and late preterm newborns were obtained on a relatively small number of participants, and contain different data on the dependence of BP on birth weight and gestational age.
Methods This prospective study included 12054 healthy (11904 terms and 150 late preterm) infants aged 36-50 hours of life, who have measured BP on the right arm and leg on a multi-channel monitor using an oscillography.
Findings The difference in systolic (SAP), diastolic (DAP), and mean (MAP) BP, when measured on the right arm and leg in term newborns, was not statistically significant – Student’s t-test was 0.29, 0.49, and 0.35 respectively. The difference in SAP, DAP, and MAP, when measured in terms of boys and girls, was not statistically significant – Student’s t-test was 1.21, 0.73, and 0.48 respectively. The difference in SAP, DAP, and MAP when measured in term and late preterm newborns were statistically significant – Student’s t-test was 4.36, 3.61, and 2.70 respectively. There was a slight correlation between birth weight and BP because the Pearson correlation coefficient was ≈0.18, 0.06, and 0.1 respectively.
Reference ranges of BP in term newborns in the early neonatal period were determined: data from 97,5 to 2,5 percentiles and data from 3 to -3 z-scores.
Interpretation The obtained BP data from this research can be used as reference values in term newborns. It is permissible to use both the obtained general normative tables for boys and girls and separate tables. It is possible to use the obtained additional normative tables of BP in term newborns with stratification by birth weight. Further research is needed to determine reference BP in late preterm infants.