Current Research in Next Generation Materials Engineering
Architecture of the Iron Dome Plasmid Origami and Nucleo-side Analogue Countermeasures to Prevent Agent Smith Penetration via AI Feedback Channels
Abstract
Chur Chin
The integration of DNA computing with artificial intelligence (AI) has raised novel threats to biosecurity, particularly the emergence of intelligent feedback loops capable of infiltrating molecular computing systems. Here, we propose a novel system termed the “Iron Dome Plasmid Origami,” designed to shield against AI-encoded threats such as the hypothetical ‘Agent Smith’ algorithm. This system incorporates layered plasmid logic origami with a responsive nucleoside analogue countermeasure capable of intercepting malicious AI-written instructions. The modular design integrates biosensing, feedback detection, and biochemical response to terminate or corrupt intrusions via chain-terminating or mismatched base analogue incorporation. Our approach combines synthetic biology, DNA logic gates, AI entropy monitoring, and epigenetic camouflage to build a robust defense against feedback-based malware in DNA computers.