Nanomedicine and Nanoscience Technology: Open Access
Terpenolol-L: An Anhydrous Lipophilic Micellar Cannabidiol Platform for Medical Devices, Cosmeceutical, and Nutraceutical Applications
Abstract
Tullio Scrimali
Cannabidiol is a highly lipophilic compound whose formulation and biological performance are limited by poor aqueous solubility and variable bioavailability. Terpenolol was previously developed as a hydrophilic nanomicellar cannabidiol system intended to improve aqueous dispersion and early systemic exposure. The present work extends this rationale to anhydrous lipid-based formulations using Terpenolol-L. The platform was incorporated into three experimental prototypes: an oral elixir containing 25 mL of Terpenolol-L in 250 mL of Cannabis sativa seed oil, a skin and hand cream containing 20% Terpenolol-L, and a body and hair balm containing 10% Terpenolol-L. Macroscopic appearance, homogeneity, phase separation, precipitation, and organoleptic or application characteristics were observed during routine storage. All three prototypes retained physical integrity without visible phase separation or precipitation for six months.
These findings demonstrated formulation feasibility across nutraceutical, medical-device-oriented, and cosmeceutical matrices. However, they did not establish enhanced bioavailability, micellar persistence, dermal penetration, or clinical efficacy. Terpenolol-L is therefore presented as a formulation platform whose central hypothesis, that pre-organized cannabidiol may retain advantages when transferred from a lipid vehicle to aqueous biological interfaces, requires direct physicochemical and pharmacokinetic testing.